Anti-Importin 13/FITC Conjugated抗体 YB--16628R-FITC报价/价

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 Anti-Importin 13/FITC Conjugated抗体

产品编号 YB-16628R-FITC 英文名称 Anti-Importin 13/FITC 中文名称 FITC标记的Importin 13蛋白抗体 别    名 Imp 13; Imp13; Importin-13; Importin13; IPO 13; IPO13; IPO13_HUMAN; Kap 13; Kap13; Karyopherin 13; Karyopherin-13; Karyopherin13; KIAA0274; Late gestation lung 2; Late gestation lung 2 protein; Lgl2; Ran binding protein 13; Ran-binding protein 13; RanBP 13; RanBP13   规格价格 100ul/2980元 购买        大包装/询价 说 明 书 100ul   研究领域 肿瘤  细胞生物  信号转导  结合蛋白  表观遗传学   抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,  产品应用 ICC=1:50-200 IF=1:50-200   not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 108kDa 性    状 Lyophilized or Liquid 浓    度 1mg/ml 免 疫 原 KLH conjugated synthetic peptide derived from human Importin 13 亚    型 IgG 纯化方法 affinity purified by Protein A 储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 产品介绍 background: This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009] Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed in fetal brain, heart, intestine and kidney. Similarity: Belongs to the importin beta family. Contains 14 HEAT repeats. Contains 1 importin N-terminal domain. Database links:

Entrez Gene: 9670 Human

Entrez Gene: 523399 Cow

Entrez Gene: 230673 Mouse

Entrez Gene: 116458 Rat

GenBank: NM_014652 Human

Omim: 610411 Human

SwissProt: A7YWD2 Cow

SwissProt: O94829 Human

SwissProt: Q8K0C1 Mouse

SwissProt: Q9JM04 Rat

Unigene: 158497 Human

Unigene: 287810 Mouse

Unigene: 14252 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications